Afsaneh Najafi - Cellular and Molecular Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran
Pegah Khosravian - Medical Plants Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran

The extensive use of antibiotics clearly drives the evolution of drug resistance in pathogenic bacteria. The multidrug resistance (MDR) is being a major challenge in world public health. A. baumannii is becoming an increasingly important human pathogen due to the emergence of MDR strains. In this study, an amine functionalized mesoporous silica nanoparticles (MSN-NH2) was synthesized and loaded by cefepime (CEF) and meropeneme (MEP). The characterization of prepared nanoparticles was done by some methods such as Scanning Electron Microscopy (SEM), nitrogen adsorption/desorption isotherms, Fourier Transform Infrared (FT-IR) spectroscopy and X-ray Diffraction (XRD) spectroscopy. Broth microdilution and well diffusion methods were used to determine antibacterial activity against MDR A. baumannii. The results showed the CEF and MEP loaded MSNs-NH2 (CEF@MSNs-NH2 and MEP@MSNs-NH2) were prepared correctly having high pay load. The antimicrobial tests results against multi drug resistant A. baumannii isolate were showed that drug loaded MSNs-NH2 more effective than free drug. The results of present study demonstrated that CEF@MSNs-NH2 and MEP@MSNs-NH2 potentiate antimicrobial activity than free drug and enhanced the possibility of combat against A. baumannii isolate.

Antibiotic resistance, Acinetobacter baumannii, mesoporous silica nanoparticles, cefepime, meropenem