Shiva Ariavand - Department of Chemistry, Mashhad Branch, Islamic Azad University, Mashhad, Iran
Mahmoud Ebrahimi - Department of Chemistry, Mashhad Branch, Islamic Azad University, Mashhad, Iran
Ebrahim Fooladi - Department of Food Safety and Quality Control, Research Institute of Food Science and Technology (RIFST), Mashhad, Iran

< p>In this study, the application of a partial least squares algorithm (PLS) was proposed for simultaneous spectrophotometric determination of acetaminophen, celecoxib, diazepam, and famotidine in hair, wastewater, and urban water samples. Although the determination of these drugs is very important in biological and pharmaceutical samples, spectrophotometric measurements were reported at the same time due to the spectral overlap. The results of applying PLS showed that acetaminophen, celecoxib, diazepam, and famotidine could be simultaneously determined within the concentration ranges of 4-20 ppm, 4-20ppm, 2-10 ppm, and 4-20 ppm respectively in calibration set, prediction set, and real samples. The proposed method does not require spectral correction and chemical pretreatment for quantitative analysis of the mentioned drugs.

Acetaminophen, Celecoxib, Diazepam, Famotidine, Partial least squares Spectrophotometry