Ali Mostafa Hassan - Chemistry Department, Faculty of Science, Al-Azhar University, Nasr City ۱۱۸۸۴, Egypt
Ahmed Osman said - Senior Researcher Chemist, Greater Cairo Water Company, Cairo, Egypt
Bassem Hussien Heakal - Research Laboratory, Cairo Oil Refining Company, Mostorod, Kaliobia, Egypt
Ahmed Younis - Green Chemistry Department, National Research Centre, ۳۳ El Bohouth St. (former EL Tahrir St.)-Dokki-Giza-Egypt-P.O.۱۲۶۲۲
Miral Ahmed Abdelmoaz - Pharmaceutical Chemistry Department, Faculty of Pharmacy, Sinai University, North Sinai, Egypt
Mahmoud Mohamed Abdrabou - Drugs Expert in the Central Administration of Chemical Laboratories Forensic Medicine, Cairo, Egypt

A tridentate Schiff base ligand (E)-1-(2-hydroxy-3-methoxybenzylidene)-3-phenylurea derived from o-vanillin and phenyl urea in 1:1 molar ratio. Also, the metal complexes of Mn (II), Co (II), Ni (II), Cu (II), Zn (II) and Zr (IV) were synthesized using the microwave-assisted irradiation and conventional methods. The ligand and its complexes 1-6 were characterized using the elemental analysis, FT-IR, UV-vis, 1HNMR, mass spectroscopy as well as thermo-gravimetric analysis (TGA). The geometry structures of the complexes were confirmed using electronic spectra, electron spin resonance (ESR) and magnetic moment. Study of the thermal dehydration and decomposition of the Co (II), Ni (II), and Zn (II) complexes kinetically using the integral method applying the Coats–Redfern and Horowitz Metzger equation. The ligand and its metal complexes were screened for the antimicrobial activity against the gram-positive, gram-negative bacteria and fungi also, the cytotoxic activity was evaluated against two cell lines; human colon carcinoma (HCT-116) and breast carcinoma cells (MCF-7).

Microwave synthesis, Metal complexes, Schiff base, O-vanillin, Phenyl urea, Thermal analysis, HCT-116, MCF-7