Study of Association Between TLR4 D299G and T399I Polymorphisms and Risk of Gastric Cancer
عنوان مقاله: Study of Association Between TLR4 D299G and T399I Polymorphisms and Risk of Gastric Cancer
شناسه ملی مقاله: JR_MCIJO-2-3_002
منتشر شده در در سال 1397
شناسه ملی مقاله: JR_MCIJO-2-3_002
منتشر شده در در سال 1397
مشخصات نویسندگان مقاله:
Hasan Hatami - AJA Cancer Epidemiology Research and Treatment Center (AJA- CERTC), AJA University of Medical Sciences, Tehran, Iran
Hamed Naghoosi - AJA Cancer Epidemiology Research and Treatment Center (AJA- CERTC), AJA University of Medical Sciences, Tehran, Iran
Mahyar Nourian - AJA Cancer Epidemiology Research and Treatment Center (AJA- CERTC), AJA University of Medical Sciences, Tehran, Iran
Mostafa Iranpour - AJA Cancer Epidemiology Research and Treatment Center (AJA- CERTC), AJA University of Medical Sciences, Tehran, Iran
Sandra Saidi - AJA Cancer Epidemiology Research and Treatment Center (AJA- CERTC), AJA University of Medical Sciences, Tehran, Iran
Mahmoud Reza Hashemi - AJA Cancer Epidemiology Research and Treatment Center (AJA- CERTC), AJA University of Medical Sciences, Tehran, Iran
Shahrokh Iravani - AJA Cancer Epidemiology Research and Treatment Center (AJA- CERTC), AJA University of Medical Sciences, Tehran, Iran
خلاصه مقاله:
Hasan Hatami - AJA Cancer Epidemiology Research and Treatment Center (AJA- CERTC), AJA University of Medical Sciences, Tehran, Iran
Hamed Naghoosi - AJA Cancer Epidemiology Research and Treatment Center (AJA- CERTC), AJA University of Medical Sciences, Tehran, Iran
Mahyar Nourian - AJA Cancer Epidemiology Research and Treatment Center (AJA- CERTC), AJA University of Medical Sciences, Tehran, Iran
Mostafa Iranpour - AJA Cancer Epidemiology Research and Treatment Center (AJA- CERTC), AJA University of Medical Sciences, Tehran, Iran
Sandra Saidi - AJA Cancer Epidemiology Research and Treatment Center (AJA- CERTC), AJA University of Medical Sciences, Tehran, Iran
Mahmoud Reza Hashemi - AJA Cancer Epidemiology Research and Treatment Center (AJA- CERTC), AJA University of Medical Sciences, Tehran, Iran
Shahrokh Iravani - AJA Cancer Epidemiology Research and Treatment Center (AJA- CERTC), AJA University of Medical Sciences, Tehran, Iran
Introduction:Gastrointestinal cancers constitute more than one-third of the most common cancers and half of the fatal cancers worldwide. Toll-like receptors (TLRs) are identified as pivotal receptors in innate immunity responses. TLR4 is the main receptor that plays a role in lipopolysaccharide (LPS) sensing of gram-positive bacteria. D299G (rs4986790) and T399I (rs4986791) polymorphisms in TLR4 lead to a decrease in immune response against LPS. The current study aimed at investigating the relationship between D299G and T399I polymorphisms and susceptibility to gastritis and gastric precancerous lesions in patients referred to Imam Reza Hospital, Tehran, Iran.
Methods:The current case-control study was conducted on 201 individuals consisting of 90 patients with gastric cancer (GC) and 111 healthy controls. Genomic DNA was extracted from peripheral blood and the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method was used to determine the mentioned polymorphisms.
Results:Allelic frequencies and genetic distribution of polymorphisms were analyzed in the patient and control groups. Although 399C and 299A allele frequencies were higher in the patients` group, the difference was not statistically significant (P > 0.05).
Conclusions: No significant association was observed between TLR4 polymorphisms on positions 299 and 399, and susceptibility to GC. Also no significant correlation was observed between these two polymorphisms and precancerous lesions. The current study results showed
that the studied polymorphisms cannot be used as a prognostic marker of GC in Iranian population.
کلمات کلیدی: Stomach Neoplasms, TLR4, Polymorphism, Single Nucleotide
صفحه اختصاصی مقاله و دریافت فایل کامل: https://civilica.com/doc/1154172/