Hossein Mehrabi - Department of Chemistry, Facualty of Science, Vali-e-Asr University of Rafsanjan, Rafsanjan, Iran
Fatemeh Dastouri - Department of Chemistry, Facualty of Science, Vali-e-Asr University of Rafsanjan, Rafsanjan, Iran

Indole cores are an important class of heterocyclic compounds found in natural products, drug molecules, and functional materials.1 They have been attention in recently years due can be exhibit a wide spectrum of biological activity such as the anti-inflammatory,2 anti-proliferative, and platelet aggregation inhibitory activities.3 Herein, we describe efficient and novel method for the synthesis of indole derivatives 4 via appropriate arylamine 1, arylglyoxal 2, and 4-hydroxycoumarin 3 in ethanol solvent at reflux conditions for 12 h. (Fig. 1). Metal-free catalyst, eco-friendly solvents, and excellent yields (80-93 %) are advantages of the protocol. All the synthesized compounds were unknown to the best of our knowledge and were characterized by 1H and 13C- NMR, IR and melting points

Indole derivatives, Arylamine, Arylglyoxal, 4-Hydroxycoumarin