Saeed Babaee - Department of Organic Chemistry, Faculty of Chemistry, Bu-Ali Sina University, Hamedan ۶۵۱۷۸۳۸۶۸۳, Iran.
Javad Afsar, - Department of Organic Chemistry, Faculty of Chemistry, Bu-Ali Sina University, Hamedan ۶۵۱۷۸۳۸۶۸۳, Iran.
Mahmoud Zarei - Department of Organic Chemistry, Faculty of Chemistry, Bu-Ali Sina University, Hamedan ۶۵۱۷۸۳۸۶۸۳, Iran.
Hassan Sepehrmansourie - Department of Organic Chemistry, Faculty of Chemistry, Bu-Ali Sina University, Hamedan ۶۵۱۷۸۳۸۶۸۳, Iran.
Mohammad Ali Zolfigol - Department of Organic Chemistry, Faculty of Chemistry, Bu-Ali Sina University, Hamedan ۶۵۱۷۸۳۸۶۸۳, Iran.

Pyrazolopyrimidines are fused heterocyclic ring systems which structurally can consider as bioisosteres of adenine, which is fundamental for every aspect of cell life. Pyrazolo[3,4-d]pyrimidine derivatives have been explored for their inhibitory activity towards various protein kinase enzymes and their role as anticancer agents [1]. On the other hand, metal organic frameworks (MOFs) as eco-friendly and green catalysts play an important role in the chemical processes. Easy recovery and reusability of these catalysts have led to their extensive use in the synthesis of a wide range of compounds [2-3]. MOFs based on the type of their ligands and functional groups on their surface exhibit different properties. Functional groups may initially be present in the organic ligand structure or after synthesizing MOFs are created. Herein, we wish to report a clean method for synthesis of the pyrazolopyrimidine derivatives under solvent free condition in the presence of MOF-Cu (10 mg) as an efficient nano-catalyst (Scheme 1).

Fused heterocyclic, Multi-component reactions, Metal organic frameworks (MOFs), Solvent free.