Mehdi Tamjid - Department of Biology, Faculty of Science, University of Mohaghegh Ardabili, Ardabil, Iran
Fariba Mahmoudi - Department of Biology, Faculty of Science, University of Mohaghegh Ardabili, Ardabil, Iran
Arash Abdolmaleki - Department of Engineering Sciences, Faculty of Advanced Technologies, University of Mohaghegh Ardabili, Namin, Iran . Bio Science and Biotechnology Research center (BBRC), Sabalan University of Advanced Technologies (SUAT), Namin, Iran.
Sharareh Mirzaee - Department of Engineering Sciences, Faculty of Advanced Technologies, University of Mohaghegh Ardabili, Namin, Iran . Bio Science and Biotechnology Research center (BBRC), Sabalan University of Advanced Technologies (SUAT), Namin, Iran.

Although the peripheral nervous system has an innate ability to repair and regenerate, this capability is limited and peripheral nerve regeneration is slow on its own. Due to the slow rate of axon regeneration, recovery of motor function is incomplete and irreversible damage to the structure and function of target organs may occur. In this study, the effects of restoring the function of sciatic nerve motor neurons following injury treated with omega-۳ coated iron oxide nanoparticles dissolved in distilled water were investigated. Forty male Wistar rats were randomly divided into four groups of ۱۰ mice in each group. Negative control group (nerve compression), sham group (surgery without nerve compression), experimental group ۱ (nerve compress with iron oxide nanoparticles coated with Omega-۳ dissolved in distilled water at a dose of ۱۰ mg / kg), Experimental Group ۲ (nerve compress with administration of iron oxide nanoparticles coated with omega-۳ dissolved in distilled water at a dose of ۳۰ mg / kg) The sciatic nerve of the right leg was then compressed one centimeter above the site of the trigeminal nerve. The footprint test was evaluated during the test period. The results showed that in the groups treated with omega-۳ coated iron oxide nanoparticles dissolved in distilled water, compared with the negative control group, the speed of the healing process and improvement of motor function increased significantly (p <۰.۰۵). The results showed that administration of omega-۳ coated iron oxide nanoparticles dissolved in distilled water has neuroprotective effects and improves motor function in the treated groups, also increases the speed of repair.

Regeneration, Peripheral nerve injuries, Nerve, Nanoparticle