Ali Moghaddam - Department of Applied Chemistry, Mashhad Branch, Islamic Azad University, Mashhad, Iran
Hassan Ali Zamani - Department of Applied Chemistry, Mashhad Branch, Islamic Azad University, Mashhad, Iran
Hasan Karimi-Maleh - Department of Chemical Engineering and Energy, Quchan University of Technology, Quchan, Iran

Monitoring tamoxifen as an anticancer drug with high side effects is so important in the chemotropic process. In this regard, a fast and simple electrochemical sensor was fabricated using a carbon paste electrode (CPE) modified with ۱-octyl-۳-methylimidazolium chloride (OMIC) and Fe۳O۴/graphene nanocomposite and utilized for tamoxifen monitoring. Fe۳O۴/graphene nanocomposite (Fe۳O۴-GR) was synthesized by a one-pot synthesis approach, following by then characterized by FESEM and EDS methods. The Fe۳O۴-GR/OMIC/CPE offered catalytic activity on the redox reaction of tamoxifen and enhanced its oxidation current about ۴.۵۹ times. Moreover, the high electrical conductivity of mediators aided the reducing the oxidation potential of tamoxifen (about ۸۰ mV) compared with the unmodified electrode. In addition, Fe۳O۴-GR/OMIC/CPE showed a linear dynamic range of ۰.۰۱ µM – ۱۵۰ µM with a detection limit of ۷.۰ nM for sensing of tamoxifen using the square wave voltammetric method. Furthermore, Fe۳O۴-GR/OMIC/CPE displayed a superior ability for sensing tamoxifen in real samples with an acceptable recovery range. In brief, Fe۳O۴-GR/OMIC/CPE provided good selectivity for sensing f tamoxifen in an aqueous solution in the presence of organic and inorganic interferences.   

Tamoxifen, ۱-octyl-۳-methylimidazolium chloride, Fe۳O۴/graphene nanocomposite, Sensor