Raed M. Muhiebes - Department of Biochemistry, College of Medicine, University of Misan, Iraq
Entesar O.Al-Tamimi - Department of Chemistry, College of Science, University of Baghdad, Jadiriya, Baghdad, Iraq

In this research new creatinine Schiff bases (۱a, ۱b, and ۱c) were synthesized from the reaction of aromatic aldehydes (۴-nitrobenzaldehyde,۴-amino benzaldehyde, and cinnamaldehyde) with creatinine, in few drops of glacial CH۳COOH as a catalyst in C۲H۵OH. Then, seven-member rings were prepared (oxazepine) (۲a-۴c) on creatinine form treatment of imines with (phthalic, maleic, and succinic anhydrides. Synthesized compounds were identified by IR, melting point, and ۱H-NMR of some of them. Some of the prepared compounds were studded with antioxidant activity.

Schiff base, oxazapane derivatives, Antioxidant activity