Ramin Saravani - Cellular and Molecular Research Center, Zahedan University of Medical Sciences, Zahedan, Iran - Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.
Hamid Reza Galavi - Cellular and Molecular Research Center, Zahedan University of Medical Sciences, Zahedan, Iran - Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.
Nafiseh Noorzehi - Department of Biology, Zabol University, Zabol, Iran
Nasrin Ranjbar - Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran
Fatemeh Mollashahee-Kohkan - Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran

Background: Perilipins are proteins at the external level of the lipid glob in adipocytes steroid-generating cells and play a central role in lipid storage and breakdown. FTO gene is associated with Type-۲ diabetes (T۲D) and increased fat mass. Association of Perilipin and FTO genes polymorphism with T۲D was investigated. Methods: Clinical traits in a random sample of ۱۸۳ Iranian men and women with T۲D and ۱۷۴ controls without any metabolic disease took part in the study. The sample was genotyped using Tetra-ARMS method. Results: In Perilipin (rs۱۰۵۲۷۰۰) polymorphism tested, a significant association was found between this polymorphism and T۲D (P=۰.۰۳). In FTO (rs۳۷۵۱۸۱۲) polymorphism, a significant association was seen between this gene and obesity (P=۰.۰۰۳). But, no significant relation was found between this genotype and T۲D. Conclusion: The rs۳۷۵۱۸۱۲ polymorphism of FTO gene is the major genetic determinant of obesity, but not type-۲ diabetes. The rs۱۰۵۲۷۰۰ polymorphism of Perilipin gene is related to T۲D but not obesity.

Type-۲ diabetes, FTO, Perilipin, gene polymorphism