Afshin Shirkani - School of medicine allergy and clinical immunology department, Blusher University of medical science, Blusher Iran.
Atena Mansouri - Student Research Committee , Nanotechnology Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
Mohammad Reza Abbaszadegan - Medical Genetics Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran-Division of Human Genetics, Immunology Research Center, Avicenna Research Institute, Mashhad University of Medical Sciences, Mashhad, Iran.
Reza Faridhosseini - Allergy Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Farahzad Jabbari Azad - Allergy Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Mehran Gholamin - Division of Human Genetics, Immunology Research Center, Avicenna Research Institute, Mashhad University of Medical Sciences, Mashhad, Iran-Department of Laboratory Sciences, School of Paramedical Sciences, Mashhad University of Medical Sciences, Mashhad,

Background:  The development of allergic rhinitis (AR) is caused by the interaction between genetic predisposition and environmental factors. In this study, the association between GATA۳ single nucleotide polymorphisms and AR in an Iranian population was identified. Methods:  This case-control study was performed on ۸۶ patients with AR and ۸۶ healthy subjects. This study aimed to evaluate a potential association between two GATA۳ SNPs, rs۱۲۶۹۴۸۶ and rs۲۲۲۹۳۶۰, and AR. Blood samples were collected and DNA was extracted for the evaluation of these SNPs by RFLP-PCR. Results: A statistically-significant association was found between rs۱۲۶۹۴۸۶ and AR (P<۰.۰۰۱). The frequencies of the A and GA genotypes were less in patients than in controls. The frequencies of the G allele and the GG genotype were greater in patients than in controls (P < ۰.۰۰۱). Conclusions: SNP rs۱۲۶۹۴۸۶ of GATA۳ was associated with AR and sensitivity to aeroallergens in our population. Because of the significance of this gene in AR, studying the association between GATA۳ polymorphisms and AR is recommended for other populations.

Allergic rhinitis, GATA۳, Genetic, SNP