Rezvan adibi - Department of Genetics and Molecular Biology, Isfahan University of Medical Sciences, Isfahan, Iran
yasin eshraghi - Department of Genetics and Molecular Biology, Isfahan University of Medical Sciences, Isfahan, Iran
Shiva moein - Department of Genetics and Molecular Biology, Isfahan University of Medical Sciences, Isfahan, Iran
Yousof Gheisari - Department of Genetics and Molecular Biology, Isfahan University of Medical Sciences, Isfahan, Iran. Regenerative Medicine Research Center, Isfahan University of Medical Sciences, Isfahan,Iran

Objective and background: Cancer recurrence is a big concern in cancer treatment. Various studies propose therapeutic approaches as suspected reason of tumor relapse. Cisplatin as the first line treatment of many types of cancers is shown leads to high rate of recurrence post treatment. Cisplatin as a DNA damaging agent causes mitotic catastrophe and subsequently cancer cells death. Nevertheless, a small number of cells survive and become polyploid. How the formation of polyploid cells is joint to cancer recurrence is a matter of debate. In this study we applied experimental and bioinformatics approaches to understand cellular and molecular mechanisms related to cisplatin-resistance(Puig et al. ۲۰۰۸).

Bioinformatics, cisplatin, Proteomics, polyploidy, cancer treatment