Hossein Hosseinzadeh - Pharmaceutical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
Fatemeh Mazaheri - Biotechnology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
Razieh Ghodsi - Biotechnology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

Objective(s): In the present study, we investigated the potential anti-nociceptive activity and acute anti-inflammatory effect of a synthetic quinoline compound (۲-(۴-Methoxyphenyl)benzo[h]quinoline-۴-carboxylic acid, QC), possessing structural elements of both naproxen and tomoxiprole drugs. Materials and Methods: The anti-nociceptive activity of QC was evaluated using chemical- and thermal-induced nociception models and its acute anti-inflammatory effect was evaluated by xylene-induced ear edema test in mice. Results: QC displayed a dose dependent effect in both acute anti-nociceptive tests (writhing and hot plate). This compound at dose of ۶.۵۶۲ mg/kg showed a high anti-nociceptive effect near equal to  diclofenac ۵ mg/kg. It also showed high anti-inflammatory effects (less than ۶.۵۶۲ mg/kg) comparable to those of reference drugs diclofenac (۵ mg/kg) and celecoxib (۱۰۰ mg/kg). Docking study showed that this quinoline derivative could inhibit COX-۲ enzyme strongly. Conclusion: QC showed high anti-nociceptive and anti-inflammatory effects comparable to reference drugs and can exert its anti-nociceptive and anti-inflammatory activities through COX-۲ inhibition.

Anti-inflammation, COX-۲, Molecular modeling, Naproxen, NSAIDs, Quinoline, Tomoxiprole