Shadi Saghafi - Department of Oral Pathology, Mashhad University of Medical Sciences, Mashhad, Iran
Sakineh Amoueian - Imam-Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran
Mehdi Montazer - Department of Pathology, Mashhad University of Medical Sciences, Mashhad, Iran
Roshanak Bostan - Mashhad University of Medical Sciences, Mashhad, Iran

Objective(s) The aim of this study was to evaluate the expressions of two angiogenic immune-markers (CD-۳۱ and VEGF), and one proliferative immune-marker (Ki-۶۷) in oral pyogenic granulomas (PG), hemangiomas (Hem) and inflammatory gingivitis (IG). Materials and Methods Sixty cases of PG, Hem and IG (twenty cases each) were examined. Immunohistochemical (IHC) staining was performed based on routine techniques. The microvessel density (MVD) index was also evaluated. Results The male to female ratio was ۱:۲. The mean age was ۳۳.۳ years old (±۲۰.۵۲). The reactivity percentages for all three markers (CD-۳۱, VEGF and Ki-۶۷) were significantly higher in PG compared to Hem (۵۶.۸%, ۱۳.۸% and ۲۳.۰% vs. ۲۸.۳%, ۷.۰% and ۵.۴%, respectively). The mean MVD in PG was also significantly higher than in Hem (۲۶.۱±۰.۱۱ vs. ۱۳.۶±۰.۰۸). There was no statistically significant difference between PG and IG. Conclusion The current study supports the common nature of pyogenic granulomas and inflammatory gingivitis.

CD۳۱, Gingivitis, Hemangioma, Ki-۶۷ Antigen, Pyogenic Granuloma, VEGF