Shubham Bhagwatrao Biradar - Department of Chemistry, Rajarshi Shahu Mahavidyalaya, (Autonomous) Latur (M. S.), India
Dnyaneshwar Vithal Narte - Department of Chemistry, Rajarshi Shahu Mahavidyalaya, (Autonomous) Latur (M. S.), India
Rushikesh Pradip Kale - Department of Chemistry, Rajarshi Shahu Mahavidyalaya, (Autonomous) Latur (M. S.), India
Kalimoddin Momin - Department of Chemistry, Rajarshi Shahu Mahavidyalaya, (Autonomous) Latur (M. S.), India.
Maroti Sudewad - Department of Chemistry, Rajarshi Shahu Mahavidyalaya, (Autonomous) Latur (M. S.), India.
Kundan Tayade - Department of Chemistry, Rajarshi Shahu Mahavidyalaya, (Autonomous) Latur (M. S.), India.
Dhananjay Palke - Department of Chemistry, Rajarshi Shahu Mahavidyalaya, (Autonomous) Latur (M. S.), India

ABSTRACTA new series of Schiff bases derived from DHA (Dehydroacetic acid) and aromatic primary amines were synthesized and characterized by elemental and spectral (Electronic, IR and ۱HNMR) analysis. The signals of ۱HNMR spectrum and characteristic peaks in IR spectra are used for the molecular structure elucidation of synthesized Schiff bases. The antimicrobial activities of synthesized compounds have been screened in vitro against Escherichia coli, Staphylococcus aureus, Bacillus subtilis bacterial species, Candida albicans and Aspergillus niger fungal organism and found to exhibit strong antifungal activity than antibacterial activity. Among the studied DHA Schiff base of ۲-amino-۴,۶-dimethylpyrimidine depicted discerning antifungal and antibacterial activities.

Keywords: Dehydroacetic acid, Schiff bases, Spectral and Biological study