Ghazaleh Alamdarnejad - Department of Polymer Engineering, Islamic Azad University, South Tehran Branch, Abozar Blvd., Ahang ۱۷۷۷۶۱۳۶۵۱ Tehran, Iran
Alireza Sharif - Department of Polymer Science and Technology, Research Institute of Petroleum Industry (RIPI), ۴th Km Karaj Highway, ۱۶۹۳۹۱۳۱۵۴ Tehran, Iran
Mohsen Janmaleki - Nanomedicine and Tissue Engineering Research Center, Shahid Beheshti University (M.C.), Taleghani Hospital, Parvaneh St., Velenjak, ۱۹۸۵۷۱۷۴۴۳ Tehran, Iran
Mohsen Dadgar - Department of Polymer Engineering, Islamic Azad University, South Tehran Branch, Abozar Blvd., Ahang ۱۷۷۷۶۱۳۶۵۱ Tehran, Iran

Thiolated carboxymethyl chitosan-β-cyclodextrin was synthesized in two steps. First, β-cyclodextrin was grafted onto carboxymethyl chitosan (CMC) by cross-linking with 1,6-hexamethylene diisocyanate (HMDI). Next, the resultant product was grafted with thioglycolic acid (TGA) with water-soluble 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDAC). The structure of product was confirmed by FT-IR. Nanoparticles of this polymer were prepared by ionic gelation method using tripolyphosphate (TPP) and analyzed with SEM and AFM.

Thiolated carboxymethyl chitosan-β-cyclodextrin, nanoparticles, controlled drug delivery