Fatemeh Moeinpour - Department of Chemistry, Payame Noor University, P.O. Box ۱۹۳۹۵-۴۶۹۷, Tehran, IRAN
Danial Moodi - Department of Animal Science Engineering, Faculty of Agriculture, Shahid Bahonar University of Kerman, Kerman, Iran
Haleh Sarabi-Omoori - Department of Chemistry, Payame Noor University, P.O. Box ۱۹۳۹۵-۴۶۹۷, Tehran, IRAN
Zarrin Eshaghi - Department of Chemistry, Payame Noor University, P.O. Box ۱۹۳۹۵-۴۶۹۷, Tehran, IRAN

The aim of the present study was to develop electrochemical sensors based on pencil graphite electrode modified with green-caped ZnO, CdO nano particles and potassium tetra chloroplatinate (II), for a simple and fast simultaneous microextraction and determination of Aspirin (ASA) and Ibuprofen (IBU). The nanoparticles were initially synthesized by the use of four vegetable extracts including garlic, onion, green onion and cabbage. The fabricated nanoparticles and platinum were then deposited on the surface of a pencil graphite electrode and was used as a working electrode in a three electrodes system. The Taguchi experimental design was employed for investigating the effects different parameters. For this purpose, a Taguchi L۱۶ orthogonal array (OA) design was applied and the results were confirmed by the ANOVA test. The electrochemical behavior of ASA and IBU at the modified electrodes, were studied. The calibration curves were linear in the range of ۵.۱۷to ۱۳۴.۰ µg.mL-۱ and ۳.۱۳ to ۲۳۱.۰ µg.mL-۱ for ASA and IBU respectively. The limits of detection for ASA and IBU was calculated to be ۰.۵۰ and ۰.۴۲ µg.mL-۱ respectively. The modified sensor showed good performance for simultaneous analysis of ASA and IBU in biological and pharmaceutical samples.

Green-Caped ZnO/ CdO Nano Particles, voltammetry, Aspirin, Ibuprofen, platinum