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Synthesis of MOF as a drug nanocarrier and evalution of its toxicity on cancer cells

عنوان مقاله: Synthesis of MOF as a drug nanocarrier and evalution of its toxicity on cancer cells
شناسه ملی مقاله: SBPFST01_013
منتشر شده در اولین کنگره ملی رویکردهای نوآورانه در سیستم بیولوژی، داروسازی وصنایع غذایی در سال 1400
مشخصات نویسندگان مقاله:

Ensieh Sadat Hossein - Department of biology- faculty of biological science-North Tehran Branch-Islamic Azad university Tehran- Iran
Maryam Bikhof Torbati - Department of Biology, Yadegar-e-Imam Khomeini (RAH) Shahr-e-Rey Branch, Islamic Azad University, Tehran, Iran
Mitra Salehi - Department of biology- faculty of biological science-North Tehran Branch-Islamic Azad university-Tehran- Iran
Mohammad Yosefi - Department of Chemistry, Faculty of Pharmaceutical Chemistry, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran

خلاصه مقاله:
MIL-۱۰۰ (Fe) was synthesized as a new class of porous, high-surface crystalline MOFs containing iron oxide (III) clusters, and then MTT assay was performed to confirm biocompatibility and non-toxicity. Introduction: Cancer is one of the leading causes of death and a major barrier to life expectancy worldwide and today, cancer is the second leading cause of death in the world (۱). In recent years, various types of materials have been introduced as semiconductors. Among them, metal-organic (MOF) frameworks have attracted much attention in industry and research centers (۲).In this study, the MIL-۱۰۰ nanocarrier was introduced as a new class of porous, high-surface crystalline MOFs containing iron oxide (III) clusters are synthesized(۳). We performed MTT testing on cancer cells, including MCF-۷.

کلمات کلیدی:
MOF, MIL-۱۰۰, Nanodrug Delivery, MTTassay

صفحه اختصاصی مقاله و دریافت فایل کامل: https://civilica.com/doc/1444372/