Mostafa Mirzaie Shalmani - Department of Chemistry, Science and Research Branch, Islamic Azad University,Tehran, Iran
Arash Alipour - Department of Chemistry, Science and Research Branch, Islamic Azad University,Tehran, Iran
Mehrnaz Babaei Shekardasht - Department of Chemistry, Science and Research Branch, Islamic Azad University,Tehran, Iran,
Parvin Gharbani - Department of Chemistry, Ahar Branch, Islamic Azad University, Ahar, Iran,

In this paper, a novel method is investigated for the extraction, determination, and delivery of ceftazidime in simulated gastric and real biological fluids such as serum plasma and urine in in vitro drug delivery systems. A new polymer as a nano-sorbent was synthesized by the surface grafting of [Nisopropylacrylamide- co-۳-allyloxy-۱,۲-propanediol] onto modified magnetic nano-particles by ۳- mercaptopropyltrimethoxysilane and it was characterized by FT-IR, CHN, SEM, TEM, VSM, TGA, and zeta potential analyses. The effects of main parameters such as pH, reaction time, temperature, and solvents were evaluated for ceftazidime removal. The results indicate that the newly synthesized polymer can be successfully applied for biomedical applications and drug delivery.

ceftazidime, in vitro drug delivery, magnetic nanoparticles, grafting copolymerization