Hadi Beitollai - NanoBioElectrochemistry Research Center, Bam University of Medical Sciences, Bam, Iran.
Sayed Zia Mohammadi - Department of Chemistry, Payame Noor University, Tehran, Iran.
Somayeh Tajik - NanoBioElectrochemistry Research Center, Bam University of Medical Sciences, Bam, Iran.

In the present work, a new sensor for morphine (MO) measurement, based on modification of screen-printed carbon electrode (SPE) by using magnetic core shell manganese ferrite nanoparticles was reported. The electrochemical behaviour of MO was investigated in phosphate buffer solution (pH ۷.۰) by voltammetry. The electrochemical response of the modified electrode toward morphine was studied by means of cyclic voltammetry (CV), differential pulse voltammetry (DPV) and chronoamperometry (CHA). The modified electrode displayed a decrease in the overpotential (ca. ۸۰ mV) and an obvious increase in the peak current was observed compared to the non-modified SPE. The results indicated that modified screen-printed electrode enhanced electrocatalytic activity towards the oxidation of MO. Under the optimized conditions the calibration curve for MO was linear from ۰.۱ – ۶۰۰.۰ μM and the detection limit based on ۳Sb/m was ۰.۰۲ µM. The application of the proposed method in analysis of real sample was also evaluated and satisfactory results were obtained.

Magnetic core shell nanoparticles, Modified electrode, Morphine determination, Screen-printed carbon electrode, Voltammetry