Zainab Amer - Department of Chemistry, College of Science, University of Baghdad, Baghdad, Iraq
Entesar O. Al-Tamimi - Department of Chemistry, College of Science, University of Baghdad, Baghdad, Iraq

The present report describes the synthesis of new the synthetic route that started by the reaction of acid hydrazide derivatives with ammonium thiocyanate to give compounds ۱a-d. ۱,۳,۴-thiadiazole derivatives ۲a-d were synthesized by the reaction compounds ۱a-d with concentration sulfuric acid. Finally, the reaction ۱,۳,۴-thiadiazole derivatives ۲a-d with sodium nitrate and hydrochloric acid in ۰-۵ °C to form diazonium salt, then diazonium salt reacted with ۴-dimethylaminobenzaldehyde to synthesize azo compounds ۳a-d. These new synthesized products were characterized by FT-IR, ۱H-NMR for some of them and were studied regarding the effect of preparing derivatives on antioxidant activity.

۱,۳,۴-thiadiazole, Azo compound, acid hydrazide, Antioxidant activity