Maryam Lohrasbi - Islamic Azad University of Khorasgan, Isfahan Branch, Shiraz, Iran.
Farzaneh Taghian - Department of Physical Education and Sport Sciences, Isfahan (khorasgan) Branch, Islamic Azad University, Isfahan, Iran.
Khosro Jalali Dehkordi - Department of Physical Education and Sport Sciences, Isfahan (khorasgan) Branch, Islamic Azad University, Isfahan, Iran.
Seyed Ali Hosseini - Department of Exercise Physiology, Marvdasht Branch, Islamic Azad University, Marvdasht, Iran.

Introduction: Multiple sclerosis (MS) is a chronic inflammatory demyelinating factor of the central nervous system that leads to decreased balance and increased risk of falls. The aim of this study was to investigate the interactive effects of endurance training (T) with royal jelly (RJ) consumption on the motor balance of rats with MS. Methods: In this experimental study, ۵۶ rats with MS (using complete Freund’s adjuvant) were divided in ۷ groups of eight animals, including: ۱) control (MS), ۲) Sham (royal jelly solvent), ۳) ۵۰ mg/kg RJ, ۴) ۱۰۰ mg/kg RJ, ۵) T, ۶) T+RJ۵۰, ۷) T+RJ۱۰۰. Rats in the royal jelly consumption groups received the prescribed doses of royal jelly peritoneally each day for ۵ weeks. Also, rats in the endurance training groups performed endurance training on a rat treadmill for five weeks, five sessions per week, each session ۳۰ minutes at a speed of ۱۱ m/min. At the end of ۴۸ hours after the last training session and royal jelly consumption, the motor balance of rats was measured using a rotarod device. Also, the weight of brain cerebellum tissue was measured by a digital scale. The one-way analysis of variance with Tukey’s post hoc test were used to analyze the findings (P≥۰.۰۵). Results: The duration of motor balance in the T, T + RJ۵۰ and T + RJ۱۰۰ groups was significantly higher than the MS group (P = ۰.۰۰۱); also, in the T + RJ۵۰ and T + RJ۱۰۰ groups, it was significantly higher than the RJ۵۰ and RJ۱۰۰ groups (P = ۰.۰۰۱). Conclusion: It appears that training and royal jelly consumption have an interactive effect on improving motor balance, and improving motor balance is training-dependent. Given the existence of effective physiological mechanisms, it seems necessary to conduct further studies by examining the pathological and physiological aspects.

Endurance training, Motor balance, Multiple Sclerosis, Royal jelly