Yasin SarveAhrabi - Department of Biology, Central Tehran Branch, Islamic Azad University, Tehran, Iran

Background: The growing spread of drug resistance in Helicobacter pylori has caused concern. Urease is oneof the most important enzymes associated with H. pylori activity. Oxadiazoles have a wide range of inhibitoryactivities. The aim of this study was to investigate new oxadiazole compounds as urease inhibitors of H. pylori.Methods: The synthesized compounds were reused as ligands in the previous study, and the initial structureof the compounds was optimized by the Molecular Mechanics Models method. Then, the compounds wereevaluated as inhibitors on the active site of the urease enzyme by AutoDock Vina software, and the outputresults were analyzed and evaluated using soft Discovery Studio software.Results: All compounds, especially (۴c) with flour groups, exhibited powerful inhibitory activity against theurease enzyme of H. pylori.Conclusions: The present findings indicated the inhibitory potential of the novel synthetic ۱, ۳, ۴-oxadiazolecompounds.

Helicobacter pylori, Urease, Oxadiazoles, Molecular docking simulation