Elahe Askari - Nutritional Health Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran.
Aziz A. Fallah - Department of Food Hygiene and Quality Control, Faculty of Veterinary Medicine, Shahre-kord University, Shahre-kord, Iran.
Saeid Habibian Dehkordi - Department of Basic Sciences, Faculty of Veterinary Medicine, Shahre-kord University, Shahre-kord, Iran.
Shahab Bahadoran - Department of Clinical Sciences, Faculty of Veterinary Medicine, Shahre-kord University, Shahre-kord, Iran.
Abdonnaser Mohebbi - Department of Clinical Sciences, Faculty of Veterinary Medicine, Shahre-kord University, Shahre-kord, Iran.
sara mohamadi - Department of Food Hygiene and Quality Control, Faculty of Veterinary Medicine, Shahre-kord University, Shahre-kord, Iran.

Introduction: Natural products can alleviate oxidative stress induced by toxic metals. This study evaluated antioxidant properties of clove essential oil (CEO), compared to oxidative deterioration of Cd. It was carried out by measuring growth performance parameters (BW, FI, and FCR), oxidative indices (TBARS, CP, CAT, SOD, and GPx), lipid profile (TG, TC, LDL-C, and HDL-C), and Cd bioaccumulation in quails. Materials and Methods: In this study, ۴۸۰ Japanese quails were fed with diets for ۳۵ days. The diets included basal diet, basal diet + VC (۵۰۰ mg/kg), basal diet + CEO (۴۵۰ mg/kg), basal diet + CEO (۱۰۰ mg/kg), basal diet + VC (۵۰۰ mg/kg) + Cd (۴۰ mg/l), basal diet + CEO (۴۵۰ mg/kg) + Cd (۴۰ mg/l), basal diet + CEO (۱۰۰ mg/kg) + Cd (۴۰ mg/l), and basal diet + Cd (۴۰ mg/l). Oxidative indices and Cd bioaccumulation (ICP-OES) were measured. Results: The major ingredients of CEO included Eugenol (۷۷.۶۳%) and β-Caryophyllene (۹.۵۵%).  Quails exposed to Cd and treated with CEO had a reduced amount of oxidative stress as evidenced by lower concentrations of TBARS and CP, higher activities of SOD, GPx, and CAT, an improved lipid profile, and lower accumulation of Cd compared to the positive control. However, FI and FCR did not change. Conclusion: Antioxidant properties of CEO were dose-dependent. CEO (۴۵۰ mg/kg) was potentially as effective as, or even more potent than VC (۵۰۰ mg/kg) in reducing the adverse effects of Cd. However, further studies are required to determine the minimum concentration of COE.

Cadmium Chloride, Oxidative Damage, Oxidative Stress, Quail.