Namita Bhutani - North DMC Medical College and Hindu Rao Hospital, Delhi, India
Shilpi Moga - Department of Pathology, SGT Medical College & University Gurugram, Haryana, India
Pooja Poswal - Department of Pathology, SGT Medical College & University Gurugram, Haryana, India
Bhanu Sharma - Department of Pathology, SGT Medical College & University Gurugram, Haryana, India
Sunil Arora - Department of Pathology, SGT Medical College & University Gurugram, Haryana, India
Sham Singla - Department of Surgery, SGT Medical College & University Gurugram, Haryana, India

Background: Breast carcinoma is the most common malignant tumor andleading cause of cancer related death in women worldwide. Apart from traditionalmarkers, estrogen receptor, progesterone receptor and Her-۲neu, which areimportant for prognostication and staging purposes, a novel markercyclooxygenase-۲ (COX-۲) is being studied extensively. We intend to study thespectrum of COX-۲ expression in normal breast tissue, ductal carcinoma in situ(DCIS) adjacent to invasive cancer, and in invasive cancer and compare COX-۲expression with histological prognostic parameters and hormone receptor status.Methods: The present study is a prospective study that was conducted in thedepartment of Pathology, SGT Medical College and Hospital, Gurugram (۲۰۱۹-۲۰۲۰). Fifty patients, aged between ۲۱ and ۷۰, suffering from primary breastcancer constituted the study group. Various histological prognostic parameterswere assessed. Immunohistochemical profile of the tumor was assessed. COX-۲score was correlated with various clinicopathologic parameters.Results: Among the total of ۵۰ patients suffering from invasive breastcarcinoma, ۹۴ percent (۴۷/۵۰) of cases showed the same COX-۲ expression levelin normal breast epithelium and corresponding tumor areas and this correlationwas statistically significant. The correlation between the level of COX-۲expression in tumor and DCIS was highly significant.Conclusion: Inhibition of COX-۲ may represent a potential target forpreventing breast cancer oncogenesis and as an adjuvant treatment followingsurgery to reduce local recurrence.

Autocrine effect, breast Cancer, carcinogenesis, COX-۲ expression, paracrine effect