Seyed Mohammad Taghi Hamidian - Babol University of Medical Sciences, Department of Gastroenterology, Babol, Iran
Rezvan Azadi - Shahid Beheshti University of Medical Sciences, Department of Medicine, Tehran, Iran
Pooya Rostami - New York University, Londgone Medical Center, Brooklyn, NY, USA
Farnaz Azar Shabe - Islamic Azad University of Tonekabon Branch, Department of Biology, Tonekabon, Iran
Zeynab Khazaee Kohparc - Islamic Azad University of Tonekabon Branch, Department of Biology, Tonekabon, Iran

Introduction: Colorectal cancer (CRC) is the third most frequent type of cancer in the world. In this explanation, genetic variation is associated in all cancers, particularly CRC, and modifications of numerous genes, such as CDX۲, CTNNBIP۱, and FAT۴, are linked to tumorgenesis in CRC. As a result, this research was conducted in order to determine changes in the expression of these genes.Materials and Methods: After obtaining patient consent and pathology department approval, from۷۲ individuals with confirmation of pathology report,were provided and bought from the Bio banks. Real-time PCR was used to examine the expression of CDX۲, CTNNBIP۱, and FAT۴ genes in tumoral and non-tumoral tissues. These genes' histological associations with grading and staging for upregulation and downregulation were examined.Result: CDX۲ (P = ۰.۰۱) and CTNNBIP۱ (P = ۰.۰۳) expression were highly increased, whereas FAT۴ (P= ۰.۰۵) expression was downregulated. Similarly, there was no evidence of a link between CDX۲ and CTNNBIP۱ overexpression and grade, stage, lymphnode metastasis, or distant metastasis. Furthermore, FAT۴ expression was linked to highe stage, high grade, distant metastasis and lymphnode metastasis (P ۰.۰۵).Conclusion: CTNNBIP۱ and CDX۲ genes were upregulated in tumoral tissues, while FAT۴ genes were downregulated. Finally, changes in the expression of these genes can be used as a CRC biomarker.

Colorectal cancer, Genes fluctuation, Regulation