Ehsan Pourtaheri - Department of Chemistry, Shahid Bahonar University of Kerman, P.O. Box ۷۶۱۷۵-۱۳۳, Kerman, Iran
Mohammad Ali Taher - Department of Chemistry, Shahid Bahonar University of Kerman, P. O. Box: ۷۶۱۷۵-۱۳۳,Kerman, Iran
Hadi Beitollahi - Environment Department, Institute of Science and High Technology and Environmental Sciences, Graduate University of Advanced Technology, Kerman, Iran

Monitoring the acetaminophen in biological samples and also in pharmaceutical formulations is important due to the concerns of public health care and drug safety. In this work a carbon paste electrode modified with BaTiO۳ nanoparticle (BTO NPs) and room-temperature ionic liquid (IL) (n-hexyl-۳-methylimidazolium hexafluoro phosphate) was fabricated. The direct electro-oxidation behavior of acetaminophen (AC) was carefully studied by cyclic voltammetry (CV), differential pulse voltammetry (DPV) and chronoamperometry (CHA) and the diffusion coefficient, D of acetaminophen at the BTOILCPE surface was estimated. The results exhibited remarkable increase in the electron transfer rate and significant decrease in the overpotential for acetaminophen oxidation reaction in contrast to that on the bare carbon paste electrode (CPE). Under the optimal conditions, using DPV the oxidation peak current was linear to the acetaminophen concentration over the range of ۱.۰ to ۶۰۰.۰ μM with a detection limit of ۰.۴۶ μM. The proposed sensor was successfully applied in pharmaceutical and urine samples with satisfactory results.

Acetaminophen, BaTiO۳ nanoparticles, Ionic Liquid, Carbon paste electrode, Voltammetry