Minoosh Lalinia - Department of Biomedical Engineering Science and Research University, Islamic Azad University, Tehran, Iran
Nahid Hassanzadeh Nemati

Metal organic frameworks (MOFs) have attracted more attention in the last decade because of a suitable large surface area, high pore volume and large porosity which may admit a broad range of drugs with different molecular sizes.Developing biocompatible MOFs such as the ZIF family (zif۸) as a drug delivery system is possible.In the present study, doxorubicin (DOX) as an anticancer drug was loaded into ZIFs MOFs to decrease the adverse side effects of pristine DOX use and to increase its efficiency through the controlled release of DOX from MOFs.The morphology of ZIF-۸ was determined by the Transmitting Electron Microscope (TEM), and the crystal structure was determined by x-ray diffraction (XRD). The Brunauer–Emmett–Teller (BET) study indicated that surface modification has little impact on the specific surface area and pore size distribution of ZIF-۸. The drug release of ZIF-۸/Doxorubicin was studied under different PH and concentrations. These nanoparticles showed excellent pH-responsive doxorubicin hydrochloride (DOX) releases due to the decomposition of ZIF-۸.The cytotoxicity was investigated with human breast adenocarcinoma cell line. These results shows that the DOX release process against MCF-۷ cells occurred in a dose dependent manner slightly more effective.

“MOFs, DOX, Drug Loading, Drug Release”.