Marzieh Gharaaty - Clinical Research Development Unit (CRDU), Sayad Shirazi Hospital, Department of Persian Medicine, School of Medicine, Golestan University of Medical Sciences, Gorgan, Iran
Mohsen Bahrami - Academic Center for Education Culture and Research, Tehran, Iran
Sadegh-Ali Azimi - Infectious Diseases Research Center, Golestan University of Medical Sciences, Gorgan, Iran
Fataneh Hashem-Dabaghian - Department of Traditional Medicine, Institute for Studies in Medical History, Persian and Complementary Medicine, School of Persian Medicine, Iran University of Medical Sciences, Tehran, Iran
Safoora Saberi - Gonbad-E-Kavoos Health center, Golestan University of Medical Sciences, Gonbad-E-Kavoos, Iran
Syed Mohd Abbas Zaidi - H.S.Z.H. Government Unani Medical College, Bhopal (M.P), India
Amir Hossein Sahebkar - Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran
Ayesheh Enayati - Ischemic Disorders Research Center, Golestan University of Medical Sciences, Gorgan, Iran

Objective: The ongoing COVID-۱۹ pandemic has been associated with clinical signs characterized by fever, fatigue and cough. Our study aimed to assess the efficacy of a Persian medicine formulation, lavender syrup, as an add-on to standard care in patients with mild to moderate COVID-۱۹.Materials and Methods: In this clinical trial which was conducted in Gorgan (Iran), ۸۴ male and female COVID-۱۹ outpatients were randomly allocated to either lavender syrup receiving ۹ ml/twice/day for ۲۱ days with standard conventional care or control groups. The primary objectives were to assess the improvement of clinical symptoms, while the secondary objectives were treatment satisfaction and anxiety levels which were evaluated once a week for ۳ weeks.Results: Out of ۸۴ participants, ۸۱ were analyzed (۴۱ in the add-on group). The comparison between groups for cough severity and anosmia showed a higher reduction in the lavender group. The effect size was ۰.۶ for cough relief. Other symptoms and the Hamilton total score decreased in both groups with no statistically significant differences between the groups. The lavender group showed greater patients’ satisfaction score.Conclusion: Adjunctive therapy with lavender syrup could reduce cough and improve the quality of life in patients with COVID-۱۹ patients.

COVID-۱۹, Cough, Herbal Medicine, Lavandula angustifolia, Persian Medicine