The effect of eight-week resistance training and consumption of grape seed nanoparticles on mitochondrial biogenesis of heart tissue in the myocardial infarction model
عنوان مقاله: The effect of eight-week resistance training and consumption of grape seed nanoparticles on mitochondrial biogenesis of
heart tissue in the myocardial infarction model
شناسه ملی مقاله: JR_SKUMS-24-4_007
منتشر شده در در سال 1401
شناسه ملی مقاله: JR_SKUMS-24-4_007
منتشر شده در در سال 1401
مشخصات نویسندگان مقاله:
Ebrahim Khaki - Department of Sports Physiology, Faculty of Sports Sciences, Isfahan (Khorasgan) Branch, Islamic Azad University, Isfahan, Iran
Khosro Jalali Dehkordi - Department of Sports Physiology, Faculty of Sports Sciences, Isfahan (Khorasgan) Branch, Islamic Azad University, Isfahan, Iran
Farzaneh Tahgian - Department of Sports Physiology, Faculty of Sports Sciences, Isfahan (Khorasgan) Branch, Islamic Azad University, Isfahan, Iran
Seyed Ali Hoseini - Department of Physical Education and Sport Sciences, Marvdasht Branch, Islamic Azad University, Marvdasht, Iran
خلاصه مقاله:
Ebrahim Khaki - Department of Sports Physiology, Faculty of Sports Sciences, Isfahan (Khorasgan) Branch, Islamic Azad University, Isfahan, Iran
Khosro Jalali Dehkordi - Department of Sports Physiology, Faculty of Sports Sciences, Isfahan (Khorasgan) Branch, Islamic Azad University, Isfahan, Iran
Farzaneh Tahgian - Department of Sports Physiology, Faculty of Sports Sciences, Isfahan (Khorasgan) Branch, Islamic Azad University, Isfahan, Iran
Seyed Ali Hoseini - Department of Physical Education and Sport Sciences, Marvdasht Branch, Islamic Azad University, Marvdasht, Iran
Background and aims: The consumption of grape seed nanoparticles extract can control cardiovascular risk factors. Exercise plays a
protective role against cardiovascular disease. Therefore, the aim of the present study was to investigate the effect of eight-week resistance
training (RT) and the use of grape seed nanoparticles on mitochondrial biogenesis of heart tissue in myocardial infarction (MI) models.
Methods: In this experimental study, ۲۵ rats were randomly divided into five groups including (۱) control (C), (۲) MI, (۳) MI + RT,
(۴) MI + grape seed, and (۵) MI + RT + grape seed. MI was induced by subcutaneous injection of isoprenaline (۸۵ mg/kg). Grape seed
nanoparticles were daily administered at a dose of ۱۵۰ mg/kg for ۸ weeks, and RT was performed ۵ days a week. Finally, data were
analyzed using the one-way analysis of variance (ANOVA) and Tukey’s post hoc tests (P ≤ ۰.۰۵).
Results: MI models showed decreased expression of PGC-۱α, PPARγ, and UCP-۱ genes in cardiac tissue (P = ۰.۰۰۱). However, RT combined
with the use of grape seed nanoparticles had a significant effect on increasing the expression of PGC-۱α (P = ۰.۰۰۱), PPARγ (P = ۰.۰۰۲), and
UCP-۱ (P = ۰.۰۰۳) genes in the heart tissue of MI model mice.
Conclusion: The consumption of grape seed nanoparticles along with RT has more effects on improving the expression of PGC-۱α, PPARγ,
and UCP-۱ genes in MI than either alone. Therefore, the use of grape seed nanoparticles together with RT is recommended in case of MI.
کلمات کلیدی: Resistance Training, Grape seed, PGC-۱α, PPARγ, UCP-۱, Myocardial infarction
صفحه اختصاصی مقاله و دریافت فایل کامل: https://civilica.com/doc/1701060/