Mitra Jalali - Department of Clinical Biochemistry, Faculty of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
Mahsa Hassanipour - ۲Department of Physiology and Pharmacology, Faculty of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran. ۳Physiology and Pharmacology Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran
Mohammadreza Hajizadeh - ۱Department of Clinical Biochemistry, Faculty of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran. ۴Molecular Medicine Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
Soudeh Khanamani Falahati Pour - ۴Molecular Medicine Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
Alireza Khoshdel - Department of Clinical Biochemistry, Faculty of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
Farzad Roustai - Department of Clinical Biochemistry, Faculty of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
Marzieh Rezai - Department of Clinical Biochemistry, Faculty of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
Mehdi Mahmoodi - Department of Clinical Biochemistry, Faculty of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran. Molecular Medicine Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.

Background and Aims: Metabolic syndrome, a common metabolic disorder, for the serious health consequences such as insulin resistance and lipid abnormalities has been considered as a major clinical challenge with obscure causes. Oxidative stress is an important component of metabolic syndrome, contributing in its development. Troxerutin, a semi-synthetic derivative of natural bioflavonoid rutin, exerts various pharmacological activities, which among all, strong anti-oxidative property is of great importance. The aim of the current study was to evaluate the effects of troxerutin on metabolic parameters and oxidative stress in metabolic syndrome induced by fructose in male rats. Materials and Methods: In order to induce metabolic syndrome, animals received the water containing ۲۰% fructose for ۸ weeks. Troxerutin was administered to animals with the dose of ۱۵۰ mg/kg orally for ۴ weeks after induction of metabolic syndrome following biochemical analysis and oxidative stress marker assessment. Results: Data showed that high-fructose diet leads to elevation of blood glucose and insulin resistance and causes abnormalities in lipid profile as well as oxidative stress enhancement (signs of a metabolic syndrome) (p<۰.۰۰۱). Troxerutin administration improved the detrimental effects of metabolic syndrome on biochemical factors and diminished oxidative stress (p<۰.۰۰۱). Conclusions: Troxerutin administration reverses the deleterious effect of metabolic syndrome in rats with high-fructose diet.

Fructose, Insulin resistance, Metabolic syndrome, Oxidative stress, Troxerutin