Saeed Balalaie - Department of Chemistry, K.N. Toosi University of Technology, P.O. Box: ۱۵۸۷۵-۴۴۱۶, Tehran, Iran Fax: +۹۸-۲۱-۲۲۸۵ ۳۶۵۰ , Balalaie@kntu.ac.ir&Balalaie@yahoo.com
Fatemeh Tahoori - Department of Chemistry, K.N. Toosi University of Technology, P.O. Box: ۱۵۸۷۵-۴۴۱۶, Tehran, Iran
Negin Khatibi - Department of Chemistry, K.N. Toosi University of Technology, P.O. Box: ۱۵۸۷۵-۴۴۱۶, Tehran, Iran

A simple and efficient one-pot, three-component Strecker reaction of protected amino acids, aromatic aldehydes, and trimethylsilyl cyanide has been developed for the synthesis of chiral α-amino nitriles. The reaction was carried out in the presence of catalytic amount of phosphotungstic acid (H۳[P(W۳O۱۰)۴]) as an environmentally friendly catalyst.

Strecker reaction, Protected α-amino acid, Heteropoly acid, Phosphotungstic acid, Trimethylsilyl cyanide, Environmentally friendly catalyst, Diastereoselectivity