Farzaneh Montazerifar - Pregnancy Health Research Center, Department of Nutrition, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran
Mansour Karajibani - Health Promotion Research Center, Department of Nutrition, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran
Mahmood Ali Keikhaie - Genetics of Non-Communicable Disease Research Center, Zahedan University of Medical Sciences, Zahedan, Iran
Maryam Mohammadi - Student Scientific Research Center, Department of Nutrition, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.
Shaghayegh Hemmat Jouy - Student Scientific Research Center, Department of Nutrition, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.
Maryam Rezaie - Department of Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.

Abstract Objective: Adiponectin and vaspin are adipocyte-derived proteins and involved in the regulation of glucose metabolism and obesity related disorders. The mechanisms that adipokines might be linked to disturbance of glucose are unclear. Thus, this study investigated the levels of serum adiponectin and vaspin, blood lipid profiles, and abdominal obesity in type ۲ diabetes (T۲DM) patients and controls. Materials and Methods: Frothy T۲DM patients and ۴۰ healthy volunteers matched by age and body mass index (BMI) were enrolled in the study. The levels of serum adiponectin, vaspin, fasting blood glucose (FBG), ۲-hr post prandial (۲hr-PP), and lipid profile were measured in both groups. Anthropometric parameters including BMI, waist circumference (WC) and waist to height ratio (WHR) were measured. Results: Higher levels of vaspin and lower levels of circulating adiponectin were observed in T۲DM patients than in the controls (P-value:۰.۰۰۰۱). In multivariate regression analyses adjusted for age and BMI, serum adiponectin levels showed a significant negative correlation with WC, WHR, FBG and duration of diabetes, and a positive correlation with HDL. While, the vaspin levels were positively correlated with WC, WHR and duration of diabetes in T۲DM patients. In addition, vaspin and adiponectin levels had negative correlation with each other. Conclusion: The findings suggested that the abdominal obesity had the highest relationship with adiponectin and vaspin in diabetic patients.

Adiponectin, Vaspin, Obesity, Type ۲ diabetes