Seyed Esmaeil Jabbari - Ph.D Student, Department of Physical Education and Sport Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran.
Mandana Gholami - Ph.D Department of Physical Education and Sport Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran.
Hojatollah Nikbakht - Ph.D Department of Physical Education and Sport Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran.
Nader Shakeri - Ph.D Department of Physical Education and Sport Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran.
Farshad Ghazalian - Ph.D Department of Physical Education and Sport Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran.

Objective: The use of non-enzymatic antioxidants in food supplements and proper exercise can have a positive effect on decreasing oxidative stress by free radical hunting. The purpose of this study was to investigate the effect of aerobic training and L-carnitine supplementation on some of the oxidative stress factors in the liver of diabetic rats. Materials and Methods: In this experimental study, ۴۵ male wistar rats (۲۰۰-۳۰۰ gr) were randomly divided into six groups: ۱) sham group, ۲) healthy control group ۳) diabetic control group, ۴) diabetic group receiving L-carnitine, ۵) diabetic group of aerobic training, ۶) diabetic group of aerobic training and receiving L-carnitine. The aerobic exercise protocol included six weeks, five sessions per week on the treadmill. After intervention, malondialdehyde (MDA), superoxide dismutase (SOD), and glutathione peroxidase (GPX) levels were determined in liver tissue. Results: Six weeks of aerobic exercise had a significant effect on MDA factor in hepatic tissue in diabetic rats (P-value: ۰.۰۲۴). However, supplementation (P-value: ۰.۸۶۸) and combined intervention of aerobic exercise and supplementation of L-carnitine (P-value: ۰.۴۶۵) did not have the significant effect on MDA factor. Also, ۶ weeks of aerobic training, supplementation of L-carnitine, and combined intervention had no significant effect on SOD and GPX factors of hepatic tissue in diabetic rats (P-value> ۰.۰۵). Conclusion: L-carnitine supplementation with regular exercise can have beneficial effects on hepatic antioxidant defense system in rats with type ۲ diabetes.

Aerobic training, L-carnitine, Antioxidant enzymes, Oxidative stress