Mehrdad Nasrollahzadeh Sabet - Faculty of Medicine, Aja University of Medical Sciences, Tehran, Iran
Saeideh Davar - Department of Epidemiology and Biostatistics, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran
Meysam Mosallaei - Department of Genetics and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
Rasoul Salehi - Department of Genetics and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
Alireza Shaygannejad - Department of Internal Medicine (Gastrointestinal Division), Faculty of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran

Background: Previous studies have demonstrated that clinicopathological features of colorectal cancer (CRC) could be diverse in different CRC patients groups. The present study aimed to analyze the association between clinicopathological characteristics and the risk factors in different CRC patients groups, which is categorized by sex, family history, age, and also primary tumor site in the Iranian CRC patients. Method: In this cross-sectional study, we included ۳۰۴ patients with CRC. The data of clinicopathological features were collected from documented pathology reports. Subsequently, we carried out multiple analyses to discover the association among these elements. Results: Our analysis demonstrated that there was a significant difference between men and women regarding the mean age at diagnosis, tumor locations, mean size of tumors, positive family history, smoking status, and physical activity (P <۰.۰۵). Out of all the patients, ۲۲.۴% had a positive family history of cancer. The patients with a positive family history just have lower mean age, body mass index (BMI), and higher physical activity compared with patients without family history of cancer (P <۰.۰۰۱). ۳۱.۹% of the patients were in the age group of below ۵۵ and ۶۸.۱% were in the age group of ۵۵. The majority of our patients in ۰.۰۵). Conclusion: Gaining information about the association between clinicopathological characteristics and the risk factors in CRC could provide a better understanding of disease pathogenesis and consequently, improve the management of diseases.

Colorectal cancer (CRC), Characteristics, Clinical presentations, Risk stratification