Marwa Elhady - Pediatric Department, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt
Heba Tawfik Okda - Pediatric Department, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt
Mohamed Farouk Ahmed - Pediatric Department, Faculty of Medicine for Boys, Al-Azhar University, Cairo, Egypt
Rasha M. Gouda - Pediatric Department, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt
Rasha Sobhy Elattar - Neurology Department, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt
Seham Eelsaid Abdelsadek - Neurology Department, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt
Talal Abd Allah Mohammed Dawa - Neurology Department, Faculty of Medicine for boys, Al-Azhar University, Cairo, Egypt
Mohammad Fathi Abdulsalam - Neurology Department, Faculty of Medicine for boys, Al-Azhar University, Cairo, Egypt
Fathy Mahmoud Mansour - Neurology Department, Faculty of Medicine for Boys, Al-Azhar University, Cairo, Egypt
Adel M. Othman - Department of Neurology, Faculty of Medicine, Damitta, Al-Azhar University
Doaa Ibrahim Hassan Ibrahim - Psychiatric Department, Faculty of Medicine (for girls), Al-Azhar University, Cairo, Egypt
Shaimaa A. Maklad - Neurology Department, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt
Shahinaz El Attar - Department of Medical Biochemistry, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt
Walaa Shipl - Department of Medical Biochemistry, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt
Rayyh A.M. Saleh - Department of Clinical Pathology, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt
Esraa Ali - Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Ain shams University, Cairo, Egypt

Background: Cognitive impairment represents a major but under-determined comorbidity in children with temporal lobe epilepsy. Exposure to oxidation stress may induce cellular damage and functional disruption in the developing brain. Method: This comparative study included ۴۲ children with newly diagnosed temporal lobe epilepsy and ۴۲ healthy children as a control group. Cognition was assessed using Wechsler Intelligence Scale. Malondialdehyde and Advanced Oxidation Protein Products were measured as markers for oxidants while plasma catalase and total antioxidant capacity was measured as markers for antioxidants. Biomarkers of oxidation stress were correlated to clinical data and cognition scores of included children.Results: Children with temporal lobe epilepsy have significant higher circulating malondialdehyde, Advanced Oxidation Protein Products and lower catalase, total anti-oxidant capacity, and cognition ability scores than healthy controls. Cognition ability scores have significant negative correlation with malondialdehyde and Advanced Oxidation Protein Products levels and significant positive correlation with the age of onset of seizures, plasma catalase and total anti-oxidant capacity levels. Conclusion: Oxidation stress may be associated with decreased cognitive abilities in children with newly diagnosed temporal lobe epilepsy. Treatment strategy for children with newly diagnosed temporal lobe epilepsy should be adjusted to decrease oxidation stress to avoid worsening of cognitive function.

Pediatrics, Oxidants, antioxidants, Cognitive Function