Vijayraj Sonawane - Department of Pharmaceutical Chemistry, SSS’s Divine College of Pharmacy, Nampur Road, Satana, Nashik, Maharashtra, India – ۴۲۳۳۰۱
Ketan Suryawanshi - Department of Pharmaceutical Chemistry, SSS’s Divine College of Pharmacy, Nampur Road, Satana, Nashik, Maharashtra, India – ۴۲۳۳۰۱
Kunal Wagh - Department of Pharmaceutical Chemistry, SSS’s Divine College of Pharmacy, Nampur Road, Satana, Nashik, Maharashtra, India – ۴۲۳۳۰۱
Saurabh Sonawane - Department of Pharmaceutical Chemistry, SSS’s Divine College of Pharmacy, Nampur Road, Satana, Nashik, Maharashtra, India – ۴۲۳۳۰۱
Anushri Sonar - Department of Pharmaceutical Chemistry, SSS’s Divine College of Pharmacy, Nampur Road, Satana, Nashik, Maharashtra, India – ۴۲۳۳۰۱
Sanjay Sakle - Department of Pharmaceutical Chemistry, SSS’s Divine College of Pharmacy, Nampur Road, Satana, Nashik, Maharashtra, India – ۴۲۳۳۰۱
Khemchand Surana - Department of Pharmaceutical Chemistry, SSS’s Divine College of Pharmacy, Nampur Road, Satana, Nashik, Maharashtra, India – ۴۲۳۳۰۱
Dhananjay Patil - Department of Pharmaceutics, SSS’s Divine College of Pharmacy, Nampur Road, Satana, Nashik, Maharashtra, India – ۴۲۳۳۰۱.
Deepak Sonawane - Department of Pharmaceutics, SSS’s Divine College of Pharmacy, Nampur Road, Satana, Nashik, Maharashtra, India – ۴۲۳۳۰۱.

This study aims to analyse and compare the disintegrating patterns of prolonged-release tablets of diclofenac sodium purchased from a variety of brands that are commercially available on the Indian national market. Each formulation contains the same quantity of the active pharmaceutical ingredient, but the excipients used may be of a different type or in a different proportion than those used in the other formulations. On the dissolution apparatus, using the same dissolution medium with a pH of ۷.۵, the effect of these formulation variations on the in vitro release qualities of the various dosage forms was compared. During the course of this investigation, it was discovered that branded formulations offered for sale by well-known pharmaceutical companies demonstrate USP-compliant release. On the other hand, formulations manufactured by local firms do not conform to the standards' requirements.

Dissolution profile, marketed formulations, comparative release, generic, branded, regulatory requirements