Motahar Heidari-Beni - Department of Nutrition, Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran.
Roya Riahi - Department of Pediatrics, Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran.
Fatemeh Mohebpour - Department of Pediatrics, Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran.
Majid Khademian - Department of Pediatrics, Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran.
Roya Kelishadi - Department of Pediatrics, Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran.

Context: There has been an increasing interest in epidemiological and clinical studies concerning the role of uric acid in cardiometabolic diseases, especially in children and adolescents. However, these potential relationships remain undiscovered; accordingly, its pathophysiological mechanisms remain unrecognized. This study aimed to assess the potential association between Serum Uric Acid (SUA) levels and cardiometabolic risk factors in a population-based sample of Iranian children and adolescents.  Objectives: This study aimed to assess the potential association between Serum Uric Acid (SUA) levels and cardiometabolic risk factors in a population-based sample of Iranian children and adolescents. Methods: The data of ۵۹۵ individuals aged ۷-۱۸ years were assessed in this research. Anthropometric measurements and laboratory tests were performed according to standardized protocols. Results: The Mean±SD age of the ۵۹۵ explored students was ۱۲.۳۹±۳.۰۷ years. The overall Mean±SD SUA level of the study participants was measured as ۴.۲۲±۱.۱۳ mg/dL, with significant gender-wise differences (۴.۰۴±۰.۹۷ mg/dL vs ۴.۳۸±۱.۲۴ mg/dL, respectively; P<۰.۰۵). The prevalence of hyperuricemia based on the ۹۰th percentile of SUA levels was equal to ۱۰.۶%. There was a positive association between SUA levels and abdominal obesity (waist circumference: ≥۹۰th percentile) [Odds Ratio (OR): ۱.۵۴; ۹۵% Confidence Interval (CI): ۱.۲۶ to ۱.۸۶] and general obesity [gender-specific Body Mass Index (BMI) for >۹۵th percentile] (OR: ۲.۳۲; ۹۵% CI: ۱.۷۴ to ۳.۱۱). Conclusions: This study suggested BMI and waist circumference as cardiometabolic risk factors, i.e. significantly associated with SUA levels in children and adolescents.

Uric acid, Metabolic syndrome, Obesity, Risk factors