Association of Rs۷۲۱۷۱۸۶ Polymorphism of Arachidonic Acid ۱۵-Lipoxygenase (ALOX۱۵) Gene with Susceptibility to Allergic Rhinitis
عنوان مقاله: Association of Rs۷۲۱۷۱۸۶ Polymorphism of Arachidonic Acid ۱۵-Lipoxygenase (ALOX۱۵) Gene with Susceptibility to Allergic Rhinitis
شناسه ملی مقاله: JR_RBMB-12-2_007
منتشر شده در در سال 1402
شناسه ملی مقاله: JR_RBMB-12-2_007
منتشر شده در در سال 1402
مشخصات نویسندگان مقاله:
Atefeh Eivazi - Student Research Committee, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Bahman Akbari - Department of Biotechnology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Sara Falahi - Student Research Committee, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Ali Gorgin Karaji - Department of Immunology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Alireza Rezaiemanesh - Department of Immunology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Seyed Hamid Reza Mortazavi - Department of Pediatrics, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Niloofar Daneshfar - Student Research Committee, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Farhad Salari - Department of Immunology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran.
خلاصه مقاله:
Atefeh Eivazi - Student Research Committee, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Bahman Akbari - Department of Biotechnology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Sara Falahi - Student Research Committee, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Ali Gorgin Karaji - Department of Immunology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Alireza Rezaiemanesh - Department of Immunology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Seyed Hamid Reza Mortazavi - Department of Pediatrics, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Niloofar Daneshfar - Student Research Committee, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Farhad Salari - Department of Immunology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Background: Allergicrhinitis (AR) is an inflammatory disorder of the nasal mucosa, caused by exposure to environmental allergens. It is known that ۱۵-lipoxygenase (۱۵-LOX) is involved in the biosynthetic pathways of anti-inflammatory lipid mediators, including resolvins and protectins.
Methods: In this study, which was performed on ۱۳۰ AR patients and ۱۳۰ healthy controls, we aimed to investigate the association of susceptibility to AR with two selected single-nucleotide polymorphisms (SNPs), that is, rs۲۶۱۹۱۱۲:A>G and rs۷۲۱۷۱۸۶:C>T, in the intron regions of arachidonic acid ۱۵-LOX (ALOX۱۵) gene, using SNPinfo and Regulome DB tools.
Results: The results showed that the CT genotype of rs۷۲۱۷۱۸۶: C>T was significantly associated with the increased risk of AR compared to the CC genotype (P= ۰.۰۳۷, OR=۱.۹۴۳, CI: ۱.۰۳۸-۰.۶۳۸). However, there was no strong evidence of the association of rs۲۶۱۹۱۱۲: A>G with susceptibility to AR (P> ۰.۰۵).
Conclusions: The present results indicated that rs۷۲۱۷۱۸۶ polymorphism of ALOX۱۵ gene might be a potential biomarker for susceptibility to AR.
کلمات کلیدی: Allergic rhinitis, Arachidonate ۱۵-lipoxygenase, Immunoresolvents, Single-nucleotide polymorphism, Specialized proresolving lipid mediators (SPMs).
صفحه اختصاصی مقاله و دریافت فایل کامل: https://civilica.com/doc/1863468/