F Baniasad - MSc, Department of Medical Physics and Biomedical Engineering, Tehran University of Medical Sciences, Tehran, Iran
B Makkiabadi - PhD, Department of Medical Physics and Biomedical Engineering, Tehran University of Medical Sciences, Tehran, Iran
R Solgi - MSc, Department of Medical Physics and Biomedical Engineering, Tehran University of Medical Sciences, Tehran, Iran
H Ghadiri - PhD, Department of Medical Physics and Biomedical Engineering, Tehran University of Medical Sciences, Tehran, Iran

Background: Recently, ultrasonic neuromodulation research has been an important and interesting issue. Ultrasonic neuromodulation is possible by the use of low-intensity transcranial focused ultrasound (tFUS) to stimulate or inhibit the neural structures. The primary capability of this method is the improvement in the treatment progress of certain neurological and psychiatric disorders noninvasively. tFUS is able to modulate ionic currents and neural depolarization, causing the alteration in electrical properties of neurons.Objective: The study aims to investigate the effect of tFUS waves on the electrical behavior of neurons using the simulation method.Material and Methods: In the first part of this simulation study, the propagation of tFUS waves throughout the head was simulated to calculate the value of acoustic pressure at the cortex. In the second part, cortical neurons were simulated by a simple model of spiking neurons proposed by Izhikevich for three common dynamics. Then, the capacitance model was proposed to determine the alteration in the electrical behavior of the neurons during tFUS stimulation. Results: At the resting state, the electric potential of the neuron’s membrane through the tFUS stimulation has an amplitude of about ۳۰ mv with the similar oscillatory behavior of the acoustic waveform; while,the ultimate electrical behavior of the neuron’s membrane indicates a decrease in the electric potential when the neurons fire.Conclusion: The electrical behavior of the neuron and the range of its membrane voltage modulated during ultrasonic stimulation. The reduction in the amplitude of membrane potential was observed while neuron spikes.

Action Potentials, Acoustic Stimulation, Ultrasonic Wave, Low Intensity Pulsed Ultrasound