Maryam Zare - Department of Biology, Faculty of Convergent Sciences and Technologies, Science and Research Branch, Islamic Azad University, Tehran, Iran
Fatemeh Moradbeygi - Department of Pharmaceutical Biotechnology, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran
Mehri Nazeri - Research Center for Molecular Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
Alaa Moeinzadeh - Department of Tissue Engineering and Regenerative Medicine, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran
Ahmad Reza Farmani - Tissue Engineering Department, School of Advanced Technologies in Medicine, Fasa University of Medical Sciences, Fasa, Iran

Background: As the wound healing process begins, activated cell types produce a large number of molecules and initiate multiple signaling pathways. Disturbances in these pathways cause abnormal wound healing and skin disorders, including keloids, hypertrophic scars, and associated chronic wounds.Materials and Methods: In this review, PubMed, ISI Web of Science, Google scholar and SCOPUS databases were searched for studies published up to October of ۲۰۲۳ related to "Mechanotransduction in Wound Healing" were addressed.Results: Studies have shown that mechanical forces can cause changes in cell function, including migration and signaling, by changing the microenvironment of a healing wound. However, despite the important role of the physical environment in skin processes, the underlying molecular mechanisms responsible for how the skin responds to force remain unclear. In the process of mechanotransduction, intracellular pathways convert mechanical signals into biochemical responses and cause the distinction between physical and chemical signaling to fade. Therefore, a better understanding of the mechanobiology of skin cells is essential in developing effective treatments to reduce skin disorders, normalize abnormal wound healing, and minimize scar formation. In addition, multiple pathways of mechanotransduction in immune cells have been identified. The central role of the immune system in directing the wound healing process through such pathways affects vital cellular functions such as activation of proliferation, cytokine production, and cell trafficking, providing a new mechanism of dynamic immune regulation during healing.Conclusion: Subsequently, considering the important effects of the mechanotransduction process on the function of immune cells present in the wound environment, especially immune cells, it is expected that understanding the mechanisms of mechanotransduction can eliminate part of the complexities of chronic wound healing and pathological complications of wounds.

Wound Healing, Mechanotransduction, Signaling, Wound Microenvironment