Fariba Noori - Department of Tissue Engineering, School of Advanced Technologies in Medicine, Fasa University of Medical Sciences, Fasa, Iran
Zahra Abpeikar - Department of Tissue Engineering, School of Advanced Technologies in Medicine, Fasa University of Medical Sciences, Fasa, Iran
Mohsen Safaei - Department of Tissue Engineering, School of Advanced Technologies in Medicine, Fasa University of Medical Sciences, Fasa, Iran
Ahmadreza Farmani - Department of Tissue Engineering, School of Advanced Technologies in Medicine, Fasa University of Medical Sciences, Fasa, Iran
Hamidreza Ghaderi Jafarbeigloo - Department of Tissue Engineering, School of Advanced Technologies in Medicine, Fasa University of Medical Sciences, Fasa, Iran
Mozhgan Jirehnezhadyan - Department of Tissue Engineering, School of Advanced Technologies in Medicine, Fasa University of Medical Sciences, Fasa, Iran

Introduction: Even with many advances in design strategies over the past decades, a large gap remains between existing tissue-engineered skin and natural skin. Reconstruction of the structure and function of the skin has remained an unsolvable problem until today. bioprinting offers an attractive and competitive solution for the fabrication of patient-specific skin grafts with multilayered biomimetic structures.Material & method: A document search was conducted on the Scopus database, Google Scholar and PubMed database of studies published from January ۲۰۱۵ to September ۲۰۲۳ with English keywords, including Bioprinting, Skin Tissue Engineering, Repair. A combined Hunt of keywords was done using Boolean drivers AND and OR. Data analysis was done qualitatively.Result: Compared to conventional skin tissue engineering approaches, bioprinting has many advantages in complex structure fabrication, spatial integration and reproducibility. In addition, bioprinted skin constructs may help improve regeneration, precise positioning of bioactive molecules, improve skin fabrication speed, reduce intervention, thus leading to better clinical outcomes. It also enables precise control of multiple combinations, spatial distributions and architectural complexity. Making ۳D skin models by bioprinter, the requirements of cells, bioink and bioprinting process should be considered in a biomimetic and spatio-temporal way due to increasing biological performance. Among the polymers used for bioprinting of skin are: gelatin, collagen, alginate, chitosan and fibrin, PEG, PCL and dECM. Stem cells and seeds are an important part of biological essences. In addition, other emerging technologies, for example, four-dimensional (۴D) bioprinting, skin-on-a-chip bioprinting, and microfluidic-assisted extrusion bioprinting, are also being used for skin tissue engineering and wound healing research.Conclusion: Recent advances in stem cell biology and various biomaterials have provided tremendous opportunities for researchers to develop and manipulate skin Bioprinting for wound healing. The availability of suitable biomaterials and advances in bioprinting technologies suggest that bioprinting can be successfully used to fabricate novel wound dressings.

Bioprinting, Skin Tissue Engineering, Repair