Sana Yahyazadeh Jasour - Department of Microbiology, School of Biology, College of Science, University of Tehran, Tehran, Iran
Farideh Mohammad Hossein Zadeh - Department of Microbiology, School of Biology, College of Science, University of Tehran, Tehran, Iran
Hoda Keshmiri Neghab - Department of Medical Laser, Medical Laser Research Center, Yara Institute, ACECR, Tehran, Iran

Skin wound healing processes are a mechanism of complex biological procedures involving many extracellular and intracellular macromolecules. it plays a significant role in remodeling and reestablishing the skin barrier following the damage. Management of the wound healing process costs billions of dollars per year directly and indirectly. Although antibiotics are applied in modern wound management as routine care, they cannot cover all aspects of wound management. Therefore, looking for an alternative strategy that accelerates the skin wound healing process is a noticeable research field for basic scientists and medical experts .Probiotics are living microorganisms, which when consumed in adequate quantities produce a beneficial effect on human health. During the last century, possible beneficial effects of probiotic bacteria on wound healing have been proposed. it is found that certain probiotic strains may improve wound healing processes through antibacterial, anti-inflammatory, and proteoglycan deposition, as well as immunomodulatory effects and angiogenesis traits.Proven mechanisms by which probiotic bacteria exert their beneficial effects include direct killing of pathogens, competitive displacement of pathogenic bacteria, reinforcement of epithelial barrier, induction of fibroblasts, and epithelial cells' migration and function. Beneficial immunomodulatory effects of probiotics relate to modulation and activation of lymphocytes, natural killer cells, and macrophages through the inducing of cytokine production. Systemic effects of beneficial bacteria and the link between gut microbiota, immune system, and cutaneous health through gut–brain–skin axes are discussed as well .Potential of beneficial probiotic species as a safe alternative approach for treatment the skin wounds and cutaneous infections is a new therapeutic perspective. Moreover, the promising industry of probiotics demonstrates a significant upsurge as more and more healthy individuals rely their well-being on alternative medicine. According to this, it is necessary to pay special attention to probiotic therapy as a helpful alternative solution in skin wound healing.

alternative strategy, probiotics, skin, wound healing