Amin Mehrabi - MA of Exercise Physiology, Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran
Farhad Daryanoosh - Associate Professor, Department of Exercise Physiology, Shiraz University, Shiraz, Iran
Maryam Amirazodi - PhD Candidate, Department of exercise physiology, International Devision of Shiraz University, Shiraz, Iran
Mohammad Ali Babaee Baigi - Department of heart and vascular, Shiraz University of Medical Sciences, Shiraz, Iran
Kouros Divsalar - MSc, Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran

Introduction: Cardiovascular homeostasis such as tonicity of vessels and blood flow can be affected by activities and hormones. The purpose of the present study was to investigate the effect of ۸ weeks low intensity aerobic exercise on plasma endothelin-۱ (ET-۱), blood pressure and heart rate (HR) in healthy men and women and coronary artery disease (CAD) patients.Methods: In this quasi-experimental study, the experimental group consisted of ۳۰ CAD patients (۱۵ males and ۱۵ females). The control group included ۱۵ healthy males and ۱۵ healthy females. These groups were chosen randomly. Participants did aerobic exercises with the intensity of ۳۰%-۴۰% of maximum HR. Blood samples were taken from participants in three stages (before, immediately and ۲۴ hours after ۸ weeks of exercise) and ET-۱ plasma level was measured by ELISA method.Results: There was no significant alteration in ET-۱ plasma level during the experiment. However, there was a significant difference in the systolic blood pressure (SBP) at the three stages in all groups (P = ۰.۰۱). In addition, we could observe a significant difference in the diastolic blood pressure (DBP) at the three stages in CAD men and healthy women (P = ۰.۰۳). Conversely, no significant difference was observed in the DBP of other groups. There was a significant difference in the blood pressure of three groups (P = ۰.۰۰۲) except for healthy men.Conclusion: The results demonstrated that, as there is a threshold in terms of time or intensity to stimulate the secretion of hormone; when the intensity and duration of exercise is below the stimulation threshold, no significant change can be observed in the level of ET-۱.

aerobic exercise, Endothelin-۱, Heart rate, Blood pressure, Coronary Artery Disease