Marjan Abdi pastaki - Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.
Saeedeh Salimi - Department of Clinical Biochemistry, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Zahra Heidari - Department of Internal Medicine, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.
Mohsen Saravani - Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran & Cellular and Molecular Research Center, Research Institute of Cellular and Molecular Sciences in Infectious Diseases, Zahedan University of Me

Background: This study explores the association between growth arrest-specific ۵ (GAS۵) rs۱۴۵۲۰۴۲۷۶, nuclear paraspeckle assembly transcript ۱ (NEAT۱) rs۵۱۲۷۱۵, and Maternally Expressed ۳ (MEG۳) rs۴۰۸۱۱۳۴ polymorphisms and their impact on susceptibility to papillary thyroid carcinoma (PTC), considering differential expression of long noncoding RNAs (lncRNAs) in PTC. Methods: A case-control study involving ۱۲۵ papillary thyroid carcinoma (PTC) patients and ۱۲۵ controls was conducted. Genotyping of polymorphisms was performed using tetra-primer amplification refractory mutation system-polymerase chain reaction (ARMS-PCR) and PCR-restriction fragment length polymorphism (PCR-RFLP) methods. Results: No significant association was found between the two groups regarding genotypes and allelic frequencies of GAS-۵ ۱۴۵۲۰۴۲۷۶ and MEG۳ rs۴۰۸۱۱۳۴ polymorphisms. Genetic models also showed the same results. Regarding NEAT۱ rs۵۱۲۷۱۵, The PTC group had more GC genotypes and over-dominant models of NEAT۱ rs۵۱۲۷۱۵ than controls, while controls showed a higher frequency of recessive models. Conclusion: GAS۵ rs۱۴۵۲۰۴۲۷۶ and MEG۳ rs۴۰۸۱۱۳۴ polymorphisms showed no significant association with papillary thyroid carcinoma (PTC) risk. In contrast, NEAT۱ rs۵۱۲۷۱۵ exhibited a significant impact on PTC development.

Gene, Growth arrest-specific ۵, Maternally expressed ۳, Nuclear paraspeckle assembly transcript ۱, Papillary thyroid carcinoma, Polymorphism.