Zahra Akbari - BSc Student, Student Research Committee, Larestan University of Medical Sciences, Larestan, Iran
Hamed Delam - MSc of Epidemiology, Student Research Committee, Larestan University of Medical Sciences, Larestan, Iran
Alireza Shahedi - BSc Student, Student Research Committee, Larestan University of Medical Sciences, Larestan, Iran

Introduction: Gardasil is a vaccine that protects the body against the HPV virus, which, in addition to itsadvantages, also has disadvantages. Therefore, the present study was designed to identify common side effectsin HPV vaccine recipients.Methods: The present study is a review study that was written in ۲۰۲۱. Medline/PubMed, Google Scholar, andWeb of Sciences databases were used to search for related articles. The keywords of this study were found usingMeSH. In the first stage, a total of ۴۲ articles were found, after applying the entry and exit criteria, this numberwas reduced to ۱۸. The inclusion criteria included: the article being Latin and the availability of the full text,and the exclusion criteria included: case report studies.Results: The most common side effect is pain at the injection site, which occurs mostly after the first dose, andstudies have mentioned headache, myalgia, and fatigue as the most common systemic side effects. Some otherstudies also include swelling, fever, itching, and chills. Nausea, feeling hot, difficulty in breathing, dizziness,and anaphylactic reaction is confirmed, and in another study conducted on HPV vaccine recipients, it was foundthat several of these people had venous thromboembolism, which according to the review Later, it was foundthat all the people studied had the risk factors of this disease. Another issue that some articles have mentionedis the deposition of vaccine aluminum in the ovary, which causes premature ovarian failure, although this issuehas not been proven yet.Conclusion: A review shows that the most common complication is pain, but there is a possibility of other sideeffects, so it is suggested that before the injection, the vaccine injectors provide the necessary training to thepeople about the purpose of the vaccine injection, expected events, and possible side effects. And it is suggestedto continue studying the effect of the HPV vaccine on venous thromboembolism and premature ovarian failure.

HPV, Vaccine, Side effects