Ali Vadizadeh - Department of Toxicology, Faculty of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran۲Toxicology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran۳Student Research Committee, Ahvaz Jundishapur University
Mahdieh Sadat Badiee - Department of Toxicology, Faculty of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran۲Toxicology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran۳Student Research Committee, Ahvaz Jundishapur University
Mohammad Javad Khodayar - Department of Toxicology, Faculty of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran۲Toxicology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
Ali Hasan Rahmani - Department of Toxicology, Faculty of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran۲Toxicology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
Ehsan Saburi - Medical Genetics and Molecular Medicine Department, Faculty of Medicine, Mashhad University of Medical Sciences,Mashhad, Iran
Armin khaleghjoo - Assistant Professor, Department of Pediatrics, Faculty of Medicine, Abadan University of Medical Sciences, Abadan,Iran.

Introduction: Gentamicin is one of the most important and effective aminoglycoside antibiotics in treatmentresistantinfections, whose frequent use leads to severe kidney toxicity. Ketotifen fumarate is a first-generationantihistamine drug and a strong stabilizer of mast cells, which has antioxidant, anti-inflammatory and antiapoptoticproperties in various models of kidney damage. The aim of this study was to investigate the protectiveeffect of ketotifen on gentamicin-induced nephrotoxicity in mice.Methods: In this study, the ameliorative effects of KTF (۲ and ۳ mg/kg, ip) on GEN (۱۰۰ mg/kg, ip) model ofkidney damage were evaluated in male mice. NMRI mice were randomly divided into ۶ groups with ۶ mice ineach group. KTF and GEN were given daily for ۷ days. On the eighth day, the animals were anesthetized, andtheir kidney tissue were removed.Results: The results indicated that KTF can ameliorate GEN-induced the significant increase in TBARS, TNF-α, and NO and decrease in the amount of total thiol, catalase, glutathione peroxidase, superoxide dismutase. Thehistopathological results confirmed indicated findings.Conclusion: The findings of this study demonstrated that ketotifen is reasonably effective in nephrotoxicitygentamicin-induced in mice

Ketotifen, Gentamicin, Nephrotoxicity, Mice