Saeid Taghavi Fardood - Department of Chemistry, Faculty of Science, Ilam University, Ilam ۶۹۳۱۵۵۱۶, Iran
Zahra Hosseinzadeh - Department of Chemistry, University of Zanjan, Zanjan, ۴۵۱۹۵-۳۱۳, Iran
Ali Ramazani - Department of Chemistry, University of Zanjan, Zanjan, ۴۵۱۹۵-۳۱۳, Iran

The primary objective of this study was to devise a straightforward and environmentally sustainable approach for creating Biginelli compounds. Accordingly, a p(AMPS) hydrogel served as an effective catalyst of diverse nature, facilitating the preparation of ۳,۴-dihydropyrimidine-۲-(۱H)-ones, commonly recognized as Biginelli compounds. The chemical process unfolded using an eco-friendly method, resulting in notably abundant product yields. Moreover, the catalyst exhibited remarkable reusability, maintaining its efficacy through four cycles without a substantial decline. The innovative Biginelli reaction technique achieves environmentally conscious synthesis, robust product generation, simplified isolation procedures, catalyst sustainability, and avoids harmful by-products.

Hydrogel, Biginelli reaction, Multi-component reactions