M Shapourgan - Department of Biomedical Engineering, Islamic Azad University, Tehran, Iran
H Mobedi - Department of Novel Drug Delivery Systems, Iran Polymer and Petrochemical Institute, Tehran, Iran,
N Sheikh - Nuclear Science and Technology Research Institute, Atomic Energy Organization of Iran, Tehran, Iran
A Behnamghader - Biomaterials Group, Nanotechnology and Advanced Materials Department, Materials and Energy Research Center, Karaj, Iran

This paper outlines the application of mathematical models for evaluation of leuprolide acetate release profile from PLGA-based in situ forming system which undergoes γ-irradiation at 8 kGy dose. PLGA-based in situ forming systems were prepared by injecting some specific amount of irradiated solution of PLGA /drug and NMP into a buffer phosphate pH 7.4 at 37 ºC. The effects of γ-ray on drug release profiles viewpoint of mathematical theory were evaluated. Hence, the experimental results of drug release approximated two commonly-used semi-empirical models: Korsmeyer-Peppas and Gallagher-Corrigan equations. The R2 values show that only Gallagher-Corrigan model is suitable for describing leuprolide acetate release from PLGAbased in situ forming system.

In situ forming systems- Poly(lactide-co-glycolide)- Leuprolide acetate- γ-Irradiation method- Mathematical models