Leila Youseftabar-Miri - Department of Chemistry, Tehran Medical Sciences Branch, Islamic Azad University, Tehran, Iran
Hamide Hosseinjani-Pirdehi - Department of Chemistry, Tarbiat Modares University,Tehran, Iran

The combination of isatins, active methylene reagents and 4- phenylurazole/ phthalhydrazide in the presence of ionic liquid ([BMIm]Cl) as a solvent catalyst was found to be a suitable and efficient method for the synthesis of the biologically important spirooxindoles. The features of this procedure were characterized by one-pot procedure, reasonable reaction times, fairly high yields, and simple isolation procedures. The ionic liquid can be easily separated and reused for several times.

Ionic liquid, Multi-compound reactions, Spirooxindole, Isatin, Pyrazole